Girija  C

Girija C

DM WIMS Medical College, Wayanad, Kerala, India

Profile ID RP-000-2496 Joined 2023-01-18 2 articles
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Articles(2)

Authors: Girija C, Muhammed Aslam K K

DOI: 10.18231/j.jdpo.2021.048  

Volume6

Issue3

Pages226-230

Abstract

Primary umbilical endometriosis is a rare condition with an overall incidence of around 0.5% to 1% among all the endometriosis cases, but at times it poses a diagnostic dilemma. In our institution we encountered a case of primary umbilical endometriosis presented to multiple surgical speciality departments. A prompt clinical examination with surgical biopsy was the key tool which lead to the diagnosis and providing a complete cure for the patient. Pelvic endometriosis affects 5-10% of women in the child bearing age group. The most pronounced symptoms are dyspareunia, pelvic pain, and infertility. Clinical presentations of umbilical endometriosis are as a nodule with or without associated umbilical pain and bleeding. This patient was given primary hormonal therapy and later underwent a biopsy which paved way for an accurate diagnosis of primary umbilical endometriosis. In this case of umbilical swelling, conditions like a benign nevus, lipoma, abscess, cyst, hernia, as well as metastatic deposit from a systemic malignancy were considered in the clinical differential diagnosis. However surgical excision helped us arrive at a definitive diagnosis and cure for the patient.   Keywords: Umbilical endometriosis, Cutaneous endometriosis, Endometriosis

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Authors: Girija C, Feroze M

DOI: 10.18231/j.ijpo.2020.111  

Volume7

Issue4

Pages556-560

Abstract

Neuroendocrine differentiation in prostatic adenocarcinoma is now one of the emerging prognostic factor that determine treatment outcome. This study aims to identify the extent of neuroendocrine differentiation amidst the tumour cells in adenocarcinoma prostate with the help of immunohistochemical marker, Chromogranin A(CgA) and correlate with its Gleason score. A semiquantative scoring system was utilised to estimate and quantify cells having neuroendocrine differentiation. Results: Out of 40 cases of prostatic adenocarcinomas in needle core biopsies, 93% of patients with a Gleason score >6 showed CgA positivity of more than 5% and 2cases (16.6%) having Gleason score 9 showed >50% of CgA positive cells in the tumour area. Conclusion: Hence higher Gleason score correlated with higher degree of neuroendocrine differentiation in our study. Keywords: Adenocarcinoma prostate, Neuroendocrine differentiation.

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