Sofia Khanam

Recently there is an increase in the interest in the secondary or non-primary metabolites produced by the marine flora and fauna. It has become the center of attraction of chemists and pharmacologists in the previous decades. Stakeholders of the natural viewpoint emphasize that the examination of new and unusual organic molecules from marine organisms while the synthetic stakeholders' faiths in targeting these novel structures for the development of new analogs and new synthetic strategies and methodologies. The chemistry of marine organisms has changed dramatically in concern of investigating rationale. Analogous to the examination of terrestrial plants, many of the recent research and studies have concentrated on the potential application of marine extracted products in the treatment, curing of human diseases, and various other works. Marine products are the major components having biomedical-oriented natural products which can be used for various purposes. Marine natural products have enough potential to work prominently and also assisting in various kinds of human needs and works. In this review, we will be focusing on prominently their works, role in biomedical-related aspects. Keywords: Marine natural products, Metabolites, Biomedical application, Marine organisms

Due to the lack of conventional therapies and the severe side effects of chemotherapy, cancer is a major public health concern across the world. After cardiac disorder, it is the second leading cause of death globally. Since ancient times, medicinal plants have been utilized to cure a variety of diseases. Natural products play an essential role in the battle against cancer and serve as a useful access source for the development and testing of novel therapeutic agents. The discovery and development of anticancer drugs can be aided by medicinal plants which contain various bioactive secondary phytochemicals viz. Alkaloids, phenolics, flavonoids, carotenoids, and other secondary metabolites. The therapeutic plants and their bioactive constituents exerted anticancer effects by induction of apoptosis, removing free radicals and antioxidant effects, inhibition of angiogenesis, and cell cycle arrest. This review explains an overview of potential therapeutic plants, including a brief description of their pharmacological effect and mechanism of action.   Keywords: Cancer, Medicinal plants phytochemicals anticancer agents.

Alzheimer’s disease (AD) is a memory-related neurodegenerative disease that affects individuals as they grow older. AD is highly devastating; beginning with memory problems and progressing to total dependency and failure to perform daily activities. Several trials have been conducted in order to discover therapeutic approaches for AD, however, the proper cure is still unavailable. Late initiation of AD drugs is argued to decrease their efficacy. While AD has no cure, symptomatic therapy can help with memory and other dementia-related issues. Due to the complexities of the underlying pathologies, the lack of diseasemodifying medications necessitates the production of newer medicinal agents and various target-based techniques. Many herbs and herbal formulations have been used for memory and cognitive enhancement in the past, and many of them have been researched thoroughly in the last few years for therapeutic efficacy in AD. The effectiveness of most herbs and plants has been confirmed in clinical trials and has been chemically tested. This study will concentrate on recent scientific results on the effectiveness of different plants in the management of AD based on their memory boosting, neuroprotective, antioxidant, and anti-inflammatory effects. Keywords: Alzheimer’s disease, Neurodegenerative disease, Medicinal plants, Therapeutic efficacy.

Insomnia Disorder is one of the most prevalent sleep disorders, and it involves both sleep complications and daytime complaints. Adequate quality sleep is crucial for good health and high quality of life. Despite this, the high prevalence and burden of insomnia disorder, which may be acute (short-term) or chronic, is growing globally. This systemic review focuses on insomnia and its management. The main causes and risk factors for insomnia are discussed, as well as the diagnostic criteria for a correct diagnosis. The treatment of insomnia, which is typically a mixture of cognitive-behavioral therapy and pharmacological treatment, is addressed, as well as the vital role pharmacists may play in not just treating insomnia but also determining the root cause/s of sleep disruptions. Keywords: Insomnia, Sleep disorder, Management, Pharmacological Treatment, Diagnosis.

Wound healing is one of the most complex and dynamic processes in the body of the human. Wound healing is an essential biological development to sustain the integrity of skin after trauma, either by accident or by a deliberate process. In the phases of hemostasis, inflammation, development, re-epithelialization, and remodeling, this includes the spatial and temporal coordination of many cell types with different functions. In understanding the mechanisms of normal wound closure, it is important to unravel the functions of these cell types and their interactions with each other. Micro-environmental changes, including changes in mechanical forces, levels of oxygen, chemokines, extracellular matrix, and synthesis of growth factor, directly influence cellular recruitment and activation, leading to disrupted wound healing conditions. Wounds are cured with different medicinal plants or from their extracts. Plants supply humans with different medicines, and medicinal plants are the blessing of nature used to heal wounds with even lower side effects. This systematic review aims to explain the physiology of the wound healing process, different cellular, and molecular aspects, and to provide insight into the various plants that have possible wound healing properties that could be valuable in healing practice.  Keywords: Wound healing, Skin injury, Hemostasis, Inflammation, Reepithelialization, Remodelling, medicinal plants.