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Abstract

Hypertension / High blood pressure is a very common disease and is a major risk factor for total organ failure, cardiovascular diseases (CVD) and premature death around worldwide. Prevalence of hypertension varies across regions and country and is dramatically variable in presentation. Sometimes it act as a silent killer i.e. the patients are unaware that they have the condition. According to estimation 46.5% of adults are unaware about their hypertensive condition, 36.9% are diagnosed and treated and the remaining 13.8% with hypertension have it under control. The investigation regarding the chronobiology, chronotherapy and chronopharmacology in treatment of hypertension began a long back ago. Hypertension is a lifestyle disease largely exhibit circadian variation. Also the condition is more evident to surge during early morning hours. Hence this requires chronotherapy. The chronobiology of hypertension along with its treatment in relation to the circadian variation is reviewed in this article.   Keywords: Hypertension, Chronobiology, Chronotherapy, Circadian rhythm, Chronopharmacology, ABPM

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Abstract

The aim of this study was to develop and evaluate floating beads of Esomrazole Magnesium USP. Floating beads of Esomeprazole was prepared by ionotropic gelatin method using sodium alginate as the polymer. Five different formulations were developed. The developed floating beads were evaluated for percentage yield, particle size, in vitro buoyancy, scanning electron microscopy and drug release. Stability studies were carried for 45 days. There are no significant change in the drug entrapment, buoyancy, and drug release of floating beads Esomeprazole Magnesium after 45 days. The polymer used was Sodium alginate. FTIR study results showed that there were no incompatibility between drug and polymer. Solubility study was performed and recorded the results. Results of our present study suggest that floating beads of Esomeprazole Magnesium can be successfully designed for controlled drug delivery which can reduce dosing frequency making the formulation an effective alternative to conventional dosage forms. Keywords: Floating beads, Esomeprazole magnesium, Buoyancy, In vitro.

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