Jyoti Parag Dekate

Abstract

Undifferentiated carcinoma with osteoclastic giant cells is a distinctive rare neoplasm involving pancreas and rarely bile ducts. This neoplasm shows characteristic histologic features with variable admixture of mononuclear histiocytic cells, non- neoplastic osteoclastic giant cells and neoplastic mononuclear cell component. Though, this tumor has been shown to share genetic alterations with pancreatic ductal adenocarcinoma, clinically, it behaves unpredictably with a substantial proportion of patient showing prolonged survival period. We present a case of this rare pancreatic tumour with brief literature review discussing the key pathologic features, immunophenotype, genetic profile and clinical behavior. Key Message: Undifferentiated carcinoma with osteoclastic giant cells is a rare neoplasm in pancreas which is believed to be of epithelial origin and shares genetic aberrations with ductal adenocarcinoma. Despite this, these tumours have better prognosis with prolonged survival period.   Keywords: Undifferentiated carcinoma, Osteoclastic giant cells

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Abstract

Sacrococcygeal teratoma is the most common congenital tumor with relatively uncommon incidence in adult population. Somatic malignancy arising in sacrococcygeal teratoma is a rare phenomena arising in long standing cases. Association with mucinous adenocarcinoma is extremely rare with only few case reports in the published literature. We herein report a case of mucinous adenocarcinoma arising in a background of sacrococcygeal teratoma with emphasis on the clinico pathological profile and post operative management of such cases. Key Messages: Somatic malignancy such as Mucinous adenocarcinoma are rarely associated with Sacrococcygeal teratoma. Adequate histopathologic sampling and microscopy is essential to clinch the diagnosis for post operative management of these patients which subsequently have a tremendous impact on patient outcome. Keywords: Teratoma, Sarcococcygeal, Mucinous adenocarcinoma, Adult.

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