Yutika Amin

Cutaneous ciliated cyst are relatively rare benign lesions, found in the dermis or subcutis of the lower extremities of young females in their second and third decades. The cysts are typically lined by ciliated cuboidal to columnar epithelium, showing pseudostratified areas and focal squamous metaplasia is occasionally present. Immunohistochemical studies have demonstrated that the cysts can be PR and ER positive, similar to the epithelia of the fallopian tubes. The pathogenesis of the cyst is yet being studied, some hypotheses have been proposed including the Mullerian heterotopias, ciliated metaplasia of eccrine sweat glands, and embryonic remnants of the cloacal membrane. We report a cutaneous ciliated cyst over the right gluteus area in a 29 year old female. On histologic examination, the cyst was lined by ciliated columnar epithelium, showing occasional papillary projections.   Keywords: Cutaneous ciliated cyst, Mullerian heterotopia, Eccrine metaplasia, Ciliated epithelium

Context: Liver disorders occupy a noteworthy proportion amongst the aetiologies for childhood morbidities and mortalities. They have characteristic histological features whose timely reporting can abet the further management and overall prognosis of the conditions. Aims: 1. To study the clinicopathological features of liver diseases in paediatric patients. 2. To analyse the histological presentation of various liver conditions in paediatric patients. 3. To assess the pattern of distribution of the conditions in different age groups of paediatric patients. Materials and Methods: A retrospective and prospective observational study of liver specimens of children, satisfying the inclusion and exclusion criterias, sent to Pathology department, BVDUMC, Pune over a span of 48 months. Statistical Analysis used: SPSS (Statistical Package for social sciences) version 24.0 software. Results: Total 34 cases were studied of which 31 were liver biopsies and 03 were resections. Most common age group was between one month to two years. Male to female ratio was 1.6:1. Most common clinical feature was icterus, LFT was deranged in 79.41% cases. Most common histopathology amongst non neoplastic cases was cholestasis and amongst neoplasms was Hepatoblastoma. Histopathology and radiology impression correlated in 94.12% cases. Bile duct proliferation, presence of intracanalicular bile plugs, portal tract fibrosis, presence of extramedullary hematopoiesis (EMH) and intracellular bile stasis all were statistically significant (p of Intracanalicular as well as intracellular bile stasis were statistically significant (p Conclusions: Thus, in children presenting with jaundice, hepatomegaly or other clinical presentations of underlying liver disease, liver biopsy can aid in understanding the underlying pathology in order to reach a definitive diagnosis and thus aid in proper management of patients in liver diseases. Keywords: Liver disease, Pediatric, Clinicopathological study, Surgical pathology.