Snehal Shende

Abstract

Introduction: Retinopathy of prematurity is one of the commonest cause of blindness in sick neonates exposed to excessive oxygen following NICU admissions. The present study was thus conducted to assess the pattern and risk factors associated with incidence of retinopathy of prematurity. Materials and Methods: A retrospective record based study was conducted at tertiary care centre between 1st July 2017 to 30thMay 2020 were screened for ROP. Baseline characteristics and risk factors for ROP were assessed. The zone and stage of ROP were categorized as per the International classification of ROP along with iris neovascularisation and plus disease as per the revised international classification of retinopathy of prematurity (ICROP) preplus disease criteria. Data was entered in excel sheet and analysed using SPSS software version 20. Results: Majority of neonates belonged to gestational age of 28 to 31 weeks (58.8%) and 51.2% neonates had birthweight of 1.5 to 2 kg. Male preponderance was observed with male: female ratio of 1.75:1. Amongst the various risk factors, the occurrence of ROP was highly significantly associated with gestational age and birthweight (p Conclusion: Early and timely screening of ROP for all high risk neonates especially low birth weight and neonates with small gestational age should be mandatory as these are the most significant risk factors associated with ROP in present study.   Keywords: ROP-Retinopathy of Prematurity.

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Abstract

Purpose: To study progression of primary open angle glaucoma in patients with maintained target intraocular pressure. Materials and Methods: This was a prospective observational study comprising 30 diagnosed patients of primary open angle glaucoma on maintained target intraocular pressure conducted for a period of 2 year. Patients underwent complete ophthalmic examination including IOP, optic disc evaluation & visual fields. Systolic and diastolic blood pressure was measured with sphygmomanometer using adult cuff size. Systolic, diastolic & mean ocular perfusion pressure ocular perfusion pressure were calculated. Patients were examined at baseline then at 12 months then at next 12 months. Progression of glaucoma was accessed on the basis of changes in VF ’ s &optic disc between baseline and final follow at 2 years. Data analyzed using standard statistical technique and a probability value ( ‘ p ’ value) of < 0> statistically significant. Results: Mean age of study participates was 540.07 years ,M:F ratio was 1.5:1.Progressive patients showed significantly changes in optic disc cupping C:D ratio f0.670.11gat baseline tof0.740.13gfinal follow up (p up(p progressive group. DBP, DOPP and MOPP were significantly lower in progressive group as compared to non-progressive group. Conclusions: Low DBP, low MOPP, and low DPP are risk factor for primary OAG progression with maintained target intraocular pressure, providing further evidence of a vascular mechanism in glaucoma pathogenesis Keywords: Primary Open Angle Glaucoma (POAG), Visuals Fields (VF), Mean Deviation (MD), Patterned standard deviation(PSD), Cup: Disc ratio (C:D), Systolic blood pressure(SBP), Diastolic blood pressure(DBP), Systolic Ocular Perfusion Pressure(SOPP), Diastolic Ocular Perfusion Pressure(DOPP), Mean Ocular Perfusion Pressure(MOPP).

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