Deepika Gujjarlapudi

Abstract

Introduction: SARS-COV-2 is has led to a worldwide pandemic COVID-19 vaccine roll out proceeds worldwide, attention is increasingly being paid to vaccination of older people that can affect vaccine efficacy. Iron deficiency anaemia and Vitamin D deficiency is a leading global cause of years lived with disability. Aims and Objective : To study the immune response in Vitamin D, Iron deficiency when compared to non deficient covid vaccinated recipients. Methods: This is a hospital based observational cross-sectional study done between April 2021 to September 2021 in elderly Indian population. Total 360 vaccine recepients attending OPD post vaccination between 15-45 days were measured anti-RBD IgG antibody & anti-spike S1/S2 antibodies, vitamin D, Iron, TIBC, HB, levels in above 60 years. Results: Out of 360 vaccine recipients, 46 had COVID-19, and we have excluded them from the study. Of the 314,They were grouped as Group I: Vitamin D deficient, Group II; Iron Deficiency, Group III :has both Deficiency of Vitamin D & Iron. GroupIV: has No Deficiency In Study I: We Compared age, sex hematological indices, vitamin D. In 314 Vaccine recipient 57.3%Male, 42.7% were female In Study II: 35% Vitamin D deficient ,30.6% Iron deficiency,23.6% had both deficiency 10.8% have no deficiency. In Study III Responses were evaluated post-vaccine RBD IgG concentration and Spike antibodies were each significantly higher among the No deficiency recipients, when compared to Iron & vitamin D Deficient recipients. Conclusions: An integrated approach is required to better understand aging & how vaccines work in elderly which will help in improving the immune response after vaccination. Keywords: Vitamin D, Iron, Deficiency, Anti spike neutralising antibodies, RBD IgG antibodies, Covid 19 vaccine efficacy

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Abstract

Introduction: IBS and IBD are two abdomen ailments commonly seen in children. IBD is a life-long disorder that includes two major forms of chronic illness UC and CD, IBS may occur when the bowel is sensitive to specific foods or other triggers like stress. Aims & Objective: The aims of the study is to investigate clinical usefulness of FC as early predictor for screening and differentiating IBD and IBS and to monitor the treatment for relapse and remission in pediatric Indian population. Materials and Methods: This was hospital based observational cohort study, conducted over a period of twelve months from January 2019 to December 2019 Total 325 patients attending OPD were included in the study, in children between 1-18years in which FC was measured using commercially available CLIA kit. HB, ESR, Hscrp were also assessed, these patients were followed up. Results: Patients were grouped asGroup I: IBS: 115(50:65M/F), Group II: 185 IBD, had Subgroup I:116 CD(48:68M/F);Group A: 62.7% presented with relapse Group B: 37.3% had disease in remission Subgroup II: 69 patients had UC(31:38 M/F); Group A: 60.9% had relapse and Group B: 39.1% in remission after follow up. Subgroup III: Others were 25(7.7%). In Study I: Levels of FC were significantly lower in patients with group I when compared to group II. In Subgroup I & Subgroup II Group A had higher FC levels when compared to group B. In Study II: A significant difference (P Conclusion: The present study showed that the determination of FC assists to differentiate between IBD and IBS also useful in monitoring of remission and in early prediction of relapse in pediatric IBD.   Keywords: Inflammatory bowel diseases (IBD) and Irritable bowel syndrome (IBS), Crohn’s disease (CD), Ulcerative colitis (UC), Disease monitoring.

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