Shaista Choudhary

Abstract

Multiple primary cancers are gradually becoming a regular condition and frequently result in many diagnostic and therapeutic difficulties. In our case report we present a 68-year female with breast lump who was incidentally diagnosed with chronic myeloid leukemia. The fine needle aspiration biopsy (FNAC) of the breast lump lead to the diagnosis of Invasive ductal carcinoma.   Keywords: Multiple primary tumors, CML, Invasive ductal carcinoma, Ph Chromosome

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Abstract

Introduction: Cytological study of body fluids has become integral part in both diagnostic and management of suspected malignant cases. The meticulous examination of body fluid for there cytomorphological properties throws light on the cause, presence of metastatic cells, typing of unknown cases, staging and prognosis of cancer. Aims and Objectives: 1) To study and evaluate current trends in cytological evaluation of body fluids for various pathological conditions in a tertiary care centre. 2) To analyse their frequency in relation to diagnosis. Materials and Methods: The present study is prospective type of analysis of 311 body fluids received in Department of pathology for duration of one year from Jan 2018 to Dec 2018 in our tertiary care centre. Results: A total of 311 body fluid samples were analyzed in this study. Pleural fluid comprised of the major bulk of the study with 120 cases followed by peritoneal fluid with 100 cases. Non-malignant diagnosis was given in majority of the cases. Slight male preponderance was noted with male to female ration 1.37:1. Conclusion: Cytological analysis of body fluid is routine diagnostic investigation which offers definite aid to the treating physician. Preliminary body fluid analysis in resource limited setups still remains the most simple, convenient and cost effective technique in reaching to a particular diagnosis. Keywords: Body fluid, Cytology, Malignant effusion, Transudate, Exudates.

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Abstract

Introduction: Mast cells are very closely linked to diseases and have a significant role in inflammatory process. The functions of mast cells depends on release of preformed granules. The aims and objectives of present study are to investigate the possible role of mast cells in pathogenesis of appendicitis. Materials and Methods: This prospective study was conducted on 100 surgically resected appendicectomy specimens at our hospital. Study period was from March 2016 to February 2017 for a period of one year. Histopathological diagnosis was made and status of mast cells was studied. Results: In this study presence of mast cells and its relationship with appendicitis was studied and it was found that increased number of mast cells were noted in inflammatory conditions of appendix. Presence of mast cells has an impact on pathology of appendix. Keywords: Appendix, Mast cells, Toluidine blue, Appendicitis.

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