Gayatri Yadav

Abstract

Background: Melasma, also called ‘chloasma’, is a common skin condition of adults in which light to dark brown or grayish pigmentation develops, mainly on the face. Although it can affect both genders and any race, it is more common in women. Melasma is an acquired pigmentary disorder described as symmetrical blotchy or splotchy hyperpigmented macules and patches. Objectives: The aim of this study was to investigate thyroid profile with anti TPO and iron, uric acid level, in male and female patients. Materials and Methods: It is a cross-sectional observational study done on 76 females and 25 male who were diagnosed with melasma and thyroid profile with anti TPO, serum iron and uric acid levels were measured. Results: In our study females were more affected then males. In females Mean ± SD value of serum TSH (5.1±2.51) and anti-TPO (11.2±3.1) levels were increased when compared to males(4.9±2.54) and (9.2±1.9). Serum iron value was low in females (83.7±30) than males (90±29). All biochemical parameter were not significant but anti TPO and FT3 showed significant (P Conclusion: Melasma is more severe in females than males. Thyroid profile is not the accurate parameter but anti TPO, and iron level are predictive marker of melasma.   Keywords: Melanocortin, Melasma.

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Abstract

Coronary heart disease is continuously increase in India. Acute myocardial infarction (AMI) and unstable angina are now recognized as part of a spectrum of clinical disease collectively known as acute coronary syndromes (ACS). The serum cholesterol binding reserve, should be a useful factor for predicting the risk of coronary heart disease. Materials and Methods: Subjects who were diagnosed clinically and chemically as CHD patients were selected out of the patients Gandhi Medical College in department of Cardiology, Hamidia Hospital, Bhopal. This study was done in 25 controls and 50 cases which were divided sexwise and age wise. There were 25 controls, 11 females and 14 males. Total coronary arterial diseases cases were 50 in number, There were 14 males & 11 females in acute coronary syndrome cases and were 14 males and 11 females stable angina. Result: The serum cholesterol was higher and SCBR was significantly lower in stable angina (25.7±7mg%) & acute coronary syndrome (60.2±6.2 mg%) as compared to controls (186.1 ± 27mg%)and (60.2±6.2 mg%). Lower SCBR the higher tendency to develop atherosclerosis and hence the higher the risk of coronary heart disease. Conclusion: It concluded that SCBR and SC maybe considered together as a better biochemical markers for the risk of atherosclerosis. Keywords: Serum cholesterol binding reserve, (SCBR), (ACS) Acute coronary syndrome, Coronary heart disease, (CHD) Stable angina (SA).

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