Authors: Vikas R. Patil, Kavan S. Warhekar, Vinay V. Sarode, Umesh A. Mahajan, Ankur Jain, Prashant P. Nikumbh
Risperidone (RIS) is an atypical antipsychotic medication. This works by selectively antagonising serotonin 5HT2 and dopamine D2 receptors. It's used to treat schizophrenia and other mental illnesses. As per literature, RIS was first approved USA by Food and drug administration (FDA) in 1993. Therefore, the main objective of this analysis of RIS in pharmaceutical and biological formulation is in both qualitative and quantitative terms. In this review article, we have summarized UV/Vis spectroscopy, high-performance liquid chromatography (HPLC), High-performance thin-layer chromatography (HPTLC), Liquid chromatography-mass spectroscopy-mass spectroscopy (LC-MS/MS) etc. based methods for estimation of risperidone. In addition to that, we have discussed the bioanalytical methods for RIS analysis. In conclusion, this review article will help to research scholars for further method development for drug estimation in pharmaceutical dosage forms and biological fluids. Keywords: Atypical antipsychotic, Analytical method, Bioanalytical methods, High performance liquid chromatography, Risperidone
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