Balaji Vijayam

Abstract

Gestational diabetes mellitus (GDM) is becoming more common all over the world, mainly to an increase in maternal obesity. There have been a number of approaches to screening for and diagnosing GDM described, however there is no consensus on which methods are the most effective. For the mother, developing fetus, and children born to mothers with GDM, GDM poses severe short and long-term health hazards. Macrosomia, shoulder dystocia, delivery trauma, and hypoglycemia in the immediate postpartum period are all short-term dangers for the fetus. Increased rates of childhood and adulthood obesity, as well as a higher cardio metabolic risk, are long-term hazards for offspring born to women with GDM. More investigations on the aetiology and underlying mechanisms of gestational diabetes and its complications on the long-term health of offspring are needed to offer a foundation for creating effective therapies during this important period with the goal of promoting lifelong health and well-being.   Keywords: Diabetes mellitus, Insulin resistance, Gestational diabetes mellitus, Macrosomia

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Abstract

Background: C-peptide levels can initially be normal or increased in type 2 diabetes mellitus (T2DM), which is connected to insulin resistance; however, as the condition progresses, these levels may fall. According to studies, kidney failure has diabetes as its primary cause, accounting for 44% of all new cases. In addition, it's critical to strictly regulate blood sugar levels and lower protein intake. Along with insulin, the pancreas produces a molecule called C-peptide. The hormone insulin regulates the body's glucose levels. Materials and Methods: A total of 300 subjects divided into 150 CKD progression diabetic nephropathy and 150 non-progressions diabetic nephropathy based on clinical parameter assessment. All patients had their body weight and body mass index (BMI) assessed. Fasting serum C peptide, HbA1C, serum creatinine, blood urea nitrogen, urine albumin, and creatinine were among the laboratory tests performed. Using the MDRD algorithm, creatinine clearance was determined from serum creatinine value. The parameters were statistically compared with respective subjects. Results: The small case-control study found a no relationship between serum C-peptide levels and both microalbuminuria and HbA1C. Conclusion: Risk of microalbuminuria may be higher in patients with low serum C peptide levels. In patients with T2DM, replacing C-peptide and administering insulin may be useful. The possibility that C-peptide may play a part in the prevention and treatment of diabetic nephropathy will need to be investigated in studies including longer-term C-peptide administration.   Keywords: C- peptide, Diabetes mellitus, HbA1C, Insulin resistance, Nephropathy.

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