Iffat Jamal

Cytoplasmic vacuolations are sometimes frequently seen in blood cells on peripheral smear but are often ignored. Presence of such vacuolations can be seen in red blood cells (RBCs) and WBCs (neutrophils, lymphocytes and monocytes). These vacuolations can be true or artefactual. Identifying this a quick, cheap and important way of guiding our diagnosis and treatment.   Keywords: Cytoplasmic, Vacuolations, Peripheral, Blood, Smear.

Filariasis is a common disease in tropical and subtropical countries including India. But only very few case reports of incidental filariasis have been observed associated with hematological malignancies. We are presenting a case of chronic lymphocytic leukemia (CLL) with associated filariasis which is a rare coincidence. It has been attributed to the immunocompromised state in hematological malignancies that make patients susceptible to parasitic infections. Keywords: Splenomegaly, Microfilariae, W bancrofti, Elephantiasis, Haematological Case History.

Inherited macrothrombocytopenia is a common condition. The aim of the review was focussing on different aspects of inherited macrohtrmbocytopenia with particular reference to India. A pubmed search of articles between January 2000 to October 2019 with keywords macrothrombocytopenia, asymptomatic macrothrombocytopenia, syndromic macrothrombocytopenia and megakaryopoeisis were searched. A total of 210 articles were found, out of which 58 articles were found related to our topic. Keywords: Inherited, Pubmed, Articles, Asymptomatic, Macrothrombocytopenia.

Ewing’s sarcoma/Primitive neuroectodermal tumor (ES/PNET) of bone is a rare childhood tumor most commonly located in the metadiaphysis. It is more commonly seen in the appendicular skeleton and typically involves femur, tibia, humerus or fibula. Within the long bones, the tumor is always metaphyseal or diaphyseal (mid-diaphysis: 33%, metadiaphysis: 44%, metaphyseal: 15%). Rarely 1%-2% of ES may involve epiphysis. In skeletally immature patients, lesions of the epiphysis are rarely malignant, with the most common diagnosis benign chondroblastoma. We report a case of ES of the tibial epiphysis in a 16 year old boy presenting with complaints of pain around right knee joint for six months associated with fever and restricted mobility of knee joint. Magnetic resonance imaging (MRI) of the patient’s right knee revealed a large lesion in the centre of upper tibial epiphysis showing hypointense signal on T1 & T2W1 extending from the articular surface through the epiphyseal plate into the upper metaphyseal region. MRI findings suggested an infective pathology with differential diagnosis of Brodie’s abscess and chondroblastoma. Based on the imaging characteristics, the patient’s age and the lesion’s location a preliminary diagnosis of chondroblastoma was made. Debridement and curettage of the lesion was performed and sent for histopathological examination. Microscopy and subsequent immunohistochemistry confirmed it to be a case of ES. An extensive research of literature was done and very few reports Of ES at epiphyseal location were found which make our case worth reporting. This case highlights the rarity of epiphyseally located Ewing sarcoma cases and thus suggesting that the diagnosis of ES should also be considered for pediatric epiphyseal tumors. Keywords: Ewing tumor, Primitive neuroectodermal tumor, Metadiaphysis, Epiphysis, Metaphyseal, Chondroblastoma.