Authors : T V. Ramani, M Pratyusha, S Saritha
DOI : 10.18231/2394-2126.2018.0126
Volume : 5
Issue : 4
Year : 0
Page No : 559-563
Introduction: The name of pancreas derives from the Greek’ word. The pancreas involves in diseases like diabetes mellitus and pancreatic cancer. It is contains Endocrine cells or Islets of Langerhans that secrete insulin, glucagon and somatostatin, which regulate blood glucose levels.1
The exocrine pancreatic acini secretes pancreatic enzymes and alpha fetoprotein which change the expression level during development and influences development and differentiation of pancreas.2
Endocrine disease causes diabetes which affects at least 200 million people worldwide, and this number is to be doubled by 2025.1 The exocrine part leads to pancreatic cancer causing about 65,000 deaths in European countries which is virtually incurable.
Aims: The purpose of the current study was to investigate microanatomy (Histogenesis) of Pancreas in aborted fresh human foetuses without any congenital abnormality. So the present study was conducted to know the development of acini and islets and their clinical correlation.
Materials and Methods: Foetuses aged between 12 to 40 weeks of gestational age and they were collected from Obstetrics and Gynaecology department of Kamineni Institute of Medical Sciences, Narkatpally, Nalgonda (Dt), Telangana, (India) and Kamineni Academy of Medical Sciences and Research centre, L.B. Nagar, Hyderabad.
The histogenic procedures were employed at all gestational ages and were discussed with the available literature because various studies have proved that the islets of pancreas are necessary for the transplantation of pancreas, but very few studies showed the importance of pancreatic acini.
Results and Conclusion: In the early weeks (12-18 weeks) the parenchyma forms primitive tubules with small lobes and lobules of acini and small spherical islets. As the age advances (18-24 weeks) the size and number of Islets are increased with encapsulation and proliferation of acinar cells.
To conclude, at the age of 18-24 weeks the fetal pancreas is suitable for organ transplantation in patients with diabetes mellitus and pancreatic cancer.
Keywords: Histogenesis, Gestational period, Pancreas, Serous acini, Islets of Langerhans, Microanatomy, Ducts, Alpha fetoprotein (AFP).