Authors : Rimsha Thaseen, Rimsha Thaseen, Rahul Sahay, Rahul Sahay, Shilpa Goyal, Shilpa Goyal, Anuj Khullar, Anuj Khullar, Dharmendra Singh, Dharmendra Singh
DOI : 10.18231/j.ijceo.2019.046
Volume : 5
Issue : 2
Year : 2019
Page No : 193-197
Introduction: Due to lack of correlation between symptoms and signs in dry eye disease, changes in tear film parameters and ocular surface health have shown wide variance across different studies worldwide. The present study evaluated the efficacy Schirmer, tear film break-up time (TBUT) and conjunctival impression cytology (CIC) in type 2 diabetics with retinopathy.
Materials and Methods: The scoring of Schirmer test, TBUT, and CIC was compared in 75 eyes of diabetics with retinopathy and 75 eyes of age and sex matched healthy controls. The diagnostic accuracy of these test for dry eye diagnosis was estimated using receiver operating curve (ROC) analysis.
Results: Dry eye indices showed a significant reduction (P<0 P=0.645), P=0.478), P=0.676) P=0.345) AUC=0.982)>TBUT (AUC=0.948) >Schirmer (AUC= 0.864), respectively.
Conclusion: Tear film characteristics and ocular surface health in patients with type 2 diabetes mellitus with retinopathy include decreased tear production as well as tear film stability with worse Nelson grade (squamous metaplasia), respectively. Second, the accuracy of CIC to evaluate dry eye in patients with diabetes was higher as compared to TBUT and Schirmer. All diabetic patients should be examined for tear film and ocular surface changes irrespective of the stage of retinopathy.
Keywords: Conjunctival impression cytology, Dry eye, Receiver operating curve, Schirmer Test, Tear film break-up time, Type 2 retinopathy.