Authors : Santosh Eknath Bidwe, Prashant Prashant, Neerja Mallick
DOI : 10.18231/j.ijcbr.2019.076
Volume : 6
Issue : 3
Year : 2019
Page No : 348-352
Introduction: Diabetes mellitus (DM) is associated with an increased risk of cardiovascular disease (CVD)
and mortality. Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are well characterized
prediabetes conditions and about half of those proceed with the development of type 2 diabetes. During the
pre-diabetic state, the risk of a CVD is modestly increased. The aim of present study is to evaluate serum
Homocysteine (Hyc) level in prediabetes and type 2 diabetes patients and find the association between Hyc
and other variables.
Materials and Methods: This cross sectional descriptive study was conducted on 450 participants. Out
of this 150 were type 2 diabetic patients, 150 prediabetes and 150 controls. Homocystine and biochemical
parameters were measured.
Results: Homocysteine is a sulfur-containing amino acid formed during the metabolism of methionine
consider as a an early detection marker in cardiovascular disease elevated in prediabetes patients, type 2
diabetes compared to controls.
Conclusion: We observed that homocysteine significantly increased in prediabetes compared to healthy
control. Homocysteine levels can indicate the risk of CVD in prediabetic stage. Prediabetes people are
under risk of CAD and type 2 diabetes. The evaluation of the Homocysteine levels may improve the early
diagnosis of CVD in prediabetes patients.
Keywords: Cardiovascular disease, Homocysteine, Nitric Oxide, Prediabetes, Type 2 diabetes.