Authors : Haruhiko Yoshioka, Miho Iwaya, Kayo Horie, Yoshihito Yokoyama, Jun Watanabe
DOI : 10.18231/j.achr.2019.042
Volume : 4
Issue : 3
Year : 2019
Page No : 220-227
Aim: The objectives of this study were to: 1) establish a nuclear grade evaluation method for endometrioid
carcinoma, and 2) evaluate the nuclear grade of each part in cases in which glandular and solid parts are
present within the same tumor, and confirm its correlation with clinicopathological factors, through which
the usefulness of this nuclear grade evaluation method was assessed.
Material and Methods: Samples were 19 preparations of specimens (4 endometrium in proliferation
phase, 8 endometrioid carcinoma G1 and 7 G3 cases) in HE-stained histological preparations (2-mm thin
sections). The nuclear grade evaluation method for endometrioid carcinoma comprises 6 items of the
nuclear atypia index and each item is scored 1-3. The nuclear grade (NG) was classified as follows based
on the total score (6-18 points): NG-I, 6-10; II, 11-13; III, 14 -18. Then, in cases in which glandular
and solid parts were present within the same tumor, the nuclear grades of these parts were separately
evaluated. The nuclear grade pattern (glandular and solid part-nuclear grade score pattern: GS-NG pattern)
was classified into 4 types: GS-NG patterns 1-4. The highest NG score in each case, designated as “ case
nuclear grade (Case-NG) ”, was positively correlated with p53 expression, and two patients who died of
primary disease were Case-NG III.
Conclusion: Histological nuclear grade evaluation method for endometrioid carcinoma, and the
significance of separately evaluating nuclear atypia of the glandular and solid structure parts, was a useful
method.
Keywords: Endometrium, Endometrioid carcinoma: EMC, Nuclear grade: NG, Case-nuclear grade: Case-NG
Glandular and solid part-nuclear grade, score pattern: GS-NG