Authors : Kalyan Ranjan Dash, Kalyan Ranjan Dash, Jagan Kumar Das, Jagan Kumar Das, Amiya Kumar Prusty, Amiya Kumar Prusty
DOI : 10.18231/j.ijpp.2019.018
Volume : 6
Issue : 3
Year : 2019
Page No : 79-82
The present study was carried out to investigate the invitro thrombolytic activity of leaf and seed extracts of Syzygium cumini. The thrombolytic activity of different concentration of extracts was compared with the standard drug Streptokinase. The blood collected from human volunteers was taken as test sample for carrying out thrombolytic activity. 800ug/ml leaf extracts of Syzygium cumini showed the mean % of clot lysis as 57.07%+/-0.76, 71.42%+/-0.75 & 86.99%+/-1.33 after incubation for 24hrs, 48hrs, and 72hrs respectively at 37?C. 800ug/ml seed extracts of Syzygium cumini showed the mean % of clot lysis as 44.93%+/-2.49, 66.58%+/-1.41, & 83.32%+/-2.27 after incubation for 24hrs, 48hrs, and 72hrs respectively at 37?C. The mean % clot lysis for the standard drug streptokinase was found to be 75.81% +/-0.71, 88.54%+/-1.02, and 93.04%+/-3.69 after incubation for 24hrs, 48hrs, and 72hrs respectively at 37?C.
Keywords: Aqueous extract, Syzygium cumini, Control, Streptokinase, In-vitro thrombolytic activity.