Intranasal midazolam: Sedation for radiological procedures

Authors : Daxa Hiren Oza, Vaibhavi Patel, Priya Pathak, Rahul C Manek, Miunalini G Patel

DOI : 10.18231/j.ijca.2019.096

Volume : 6

Issue : 4

Year : 2019

Page No : 493-496

Context: Preoperative stress, anxiety and lack of cooperative ability of paediatric patients need sedation
for radiological procedure.
Aims: The purpose of study is to compare and evaluate efficiency and safety of two doses of intranasal
Settings and Design: This is a prospective Randomized controlled study of interventional type of study.
Methods and Material: Sixty patient of age 1 to 4 years, ASA 1 and ASA2 undergoing radiological
procedure were randomly divided into two groups. Group A received 0.3 mg/kg and Group B received
0.5 mg/kg of intranasal spray of midazolam. Sedation score, haemodynamic variations, ease of separation,
Venepunture response and side effect were studied.
Statistical analysis used: Data analysis was performed using SPSS for Windows, version 20.0(SPSS Inc.,
Chicago, IL)
Results: Higher sedation score achieved earlier with 0.5mg/kg dose, Parenteral separation and IV line
insertion was more easier with 0.5 mg/kg dose but recovery slight delay compare to 0.3 mg/kg dose after
20 min of procedure completion but there was no much prolongation of recovery time, at 30 min of all
patient discharged in both groups.
Conclusions: High Sedation score, parentral separation and response to IV line was earlier and easier with
0.5 mg/kg dose.
Key Messages: Intranasal Midazolam is safe and effective as sedative in paediatric radiological procedure.

Keywords: Intranasal, Midazolam, Radiological procedure.

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