Authors : Pradhan M Pagaro, Anushree S Gambhir, Neekita S Agrawal, Piyusha Ulhas Naragude, Pooja Pathak
DOI : 10.18231/j.ijpo.2019.117
Volume : 6
Issue : 4
Year : 2019
Page No : 603-609
Introduction: Soft tissue encompasses the supportive connective tissue of various organs and the other
nonepithelial, extra skeletal structures excluding the viscera, lymphoreticular system and meninges. The
aim & objectives were to study the histopathological spectrum of various soft tissue tumours (STTs), to
know the proportion of benign, intermediate and malignant soft tissue tumours and to know the age, gender
and site distribution of these tumours.
Materials and Methods: It was a pro spective study of 100 cases carried out at the Department of
Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra. All
specimens were received in 10% buffered formalin and processed through standard paraffin embedding
technique. Sections of 3-5 micrometre thickness were cut and stained with Haematoxylin and Eosin stain.
All STTs were classified as per the 2013 WHO classification.
Results: Out of the 100 cases of STTs, 90% were benign, 2% were intermediate and 8% were malignant.
Sarcomas showed a predominance above the sixth decade. STTs showed a male preponderance with a male
to female ratio of 1.3, while a female predominance was seen in the malignant STTs. Majority of the STTs
were located on the extremities (35%), followed by the head and neck region (32%). Adipocytic tumours
(55%) were the most common STTs, followed by nerve sheath tumours (18%) and vascular tumours (14%).
Conclusion: In spite of various ancillary techniques like special stains, immunohistochemistry, in situ
hybridization (ISH) and molecular genetics, histopathological examination remains the gold standard for
proper diagnosis of soft tissue tumours.
Keywords: Soft tissue, Histopathology, Benign, Malignant, Lipoma, Sarcoma.