Authors : Pradip Butale, Balawant Kove, Mangesh Tekade
DOI : 10.18231/j.ijpo.2019.131
Volume : 6
Issue : 4
Year : 2019
Page No : 695-699
Aim and Objectives: The present study was undertaken to evaluate the relation between various type of
arthritis and lipid profile. This was a comparative study in which lipid profile of arthritis patients were
statistically compared with age and sex matched controls.
Materials and Methods: During one year of study period, a total of 150 clinically diagnosed cases
of arthritis and 75 ages and sex matched controls were studied, regarding demographic characteristics,
clinical characteristics and biochemical changes with special reference to lipid profile in relation to the
type of arthritis and severity of arthritis.
Results: There was no relation found between age/gender and lipid profile. Rheumatoid arthritis (RA) was
the most common type of arthritis and knee joint was commonest involved joint. RA factor was negative in
majority of cases (63%) and mean ESR of cases was 40.2 mm. Peri-articular osteopenia was the commonest
radiological finding. The frequency of cases with hypercholesterolemia, hyper triglyceridemia and low
HDL value was 13.33%, 16.67% and 70.67% respectively. There was no significant difference found
between cases and controls in regards to serum total cholesterol (TC), triglycerides, HDL, LDL, VLDL
levels, TC/HDL and LDL/HDL ratio. In different types of arthritis, there was a statistically significant
difference was found in the mean HDL levels while no significant difference in the mean of TC, LDL,
VLDL, and triglyceride levels.
Conclusion: Study reveals that the lipid profile is altered in RA characterized by low TC and LDL with
lower RA factor titres. However, the mean triglycerides, HDL, LDL, VLDL, TC/HDL and mean LDL/HDL
did not show a significant difference between subgroups of the patients having different titres of RA factor.
Keywords: Lipid profile, Arthritides, Rheumatoid arthritis, Periarticular osteopenia, Hypercholesterolemia, Hypertriglyceridemia, RA factor.