Authors : Priya Patil, Priya Patil, Padmaja Nikam, Padmaja Nikam, Naren Nimbal, Naren Nimbal, Shashikant Nikam, Shashikant Nikam
DOI : 10.18231/j.ijcbr.2019.114
Volume : 6
Issue : 4
Year : 2019
Page No : 546-552
Introduction: Type 2 diabetes mellitus (T2DM) is the leading cause of death among non-communicable
diseases. The cause for T2DM is multi-factorial and the consequence of hyperglycaemia are many like
altered lipid profile, increased oxidative stress, increased amount of altered albumin in circulation i.e.,
ischemia modified albumin (IMA). All these alterations would lead to microvascular and macrovascular
complications. Therefore treating T2DM with hypoglycaemic drugs and insulin alone is failing to achieve
the long term glycaemic control. Hence there is need for supportive therapy like yoga. The aim of the
study was to determine the effect of yoga practicing on IMA, lipid profile and antioxidant enzymes in
T2DM patients on oral hypoglycaemic drugs (OHD).
Materials and Methods: This was a prospective cohort study, conducted from June 2017 to October 2018.
Two hundred T2DM patients were included in the study. In group I 100 T2DM patients on Metformin
and Glimipride (500 mg BD + 2 mg OD, respectively) along with yoga practicing were included and in
group II there were 100 T2DM patients of age and duration of T2DM ma tched with out practicing yoga.
The levels of Fasting plasma glucose (FPG), Post prandial plasma glucose(PPPG), Glycated hemoglobin
(HbA1c), Ischemia modified albumin (IMA), Lipid profile (TC, Tg, LDL-C, VLDL-C, HDL-C), lipid
peroxidation (Malondialdehyde levels) and activity of enzymatic antioxidants (Superoxide dismutase,
catalase, Glutathione peroxidase) were measured in both groups.
Glycemic profile (FPG, PPPG, HbA1C, IMA), Lipid profile and oxidative stress were comparable in
patients of both groups. Patients on oral hypoglycemic drugs (OHD) and yoga practicing showed
significantly lower ed levels of FPG, PPPG, HbA1C, IMA, TC, TG, LDL-C and MDA and significantly
increased levels of HDL-C, SOD, Catalase and GPx in comparison with T2DM patients those who were
only on OHD.
Reduced Oxidative stress, decreased lipids profile and Glycemic control was seen in yoga practicing T2DM
patients than in those who were only on OHD. Practicing of yoga with OHD in T2DM patients will improve
the glycemic index, reduce risk of MI and help to prevent the CVD complications. Hence this study
suggests to practice yoga with OHD to reduce further complications of T2DM.
Keywords: T2DM, Ischemia modified albumin, Lipid profile, Oxidative stress.