Authors : Sumant Kumar Singh, Sumant Kumar Singh, Amit Kumar Srivastava, Amit Kumar Srivastava, Manoj Kumar, Manoj Kumar, Arpita Srivastava, Arpita Srivastava, Harish Tiwari, Harish Tiwari
DOI : 10.18231/j.ijohd.2019.047
Volume : 5
Issue : 4
Year : 2019
Page No : 208-211
Aims: The aim of this study was to evaluate the role of Dexamethasone (Steroidal anti-inflammatory drug) and Ibuprofen (Nonsteroidal anti-inflammatory drug) in controlling postoperative pain and swelling following gingivectomy procedure when administered preoperatively.
Materials and Methods: It was triple blind placebo controlled clinical trial in which total of 60 patients were randomly allocated for external bevel gingivectomy. All patients were divided in three groups as follows: In Group A: Tab Dexamethasone 4mg, Group B:Tab Ibuprofen 400mg and in Group C: Placebo tab orally given to the patients 30 minutes before gingivectomy procedure. Pain intensity were evaluated using visual analog scale(VAS) at 6hr, 12hr, 24hr, day 2 and on day3 postgingivectomy period and swelling scores at day 1,day 2 and on day 3 postgingivectomy period using visual scoring system. The data collected were statistically analysed using one way analysis of variance (ANOVA) test.
Result & Conclusion: At 6hr and 12hr postgingivectomy period pain intensity was almost same with Group A (Dexamethasone) and Group B (Ibuprofen) and was maximum with Placebo group. At 24hr, day 2 and day 3 postgingivectomy period, the pain intensity was least with Dexamethasone group followed by Ibuprofen then Placebo group. It was found that at day 1 postgingivectomy period swelling was significantly less with Dexamethasone group followed by Ibuprofen group then Placebo group. The present study showed that Dexamethasone is better than Ibuprofen in controlling pain and edema following gingivectomy procedure.
Keywords: Steroidal anti-inflammatory drugs (SAIDs), Nonsteroidal anti-inflammatory drugs (NSAIDs), Central sensitization, Peripheral sensitization, Cyclooxygenase pathway, Phospholipase enzyme.