Authors : Ramya Potti, Ramya Potti, Venkata Renuka Inuganti, Venkata Renuka Inuganti, Chaitra B, Chaitra B, Garima B, Garima B, Durga Prasad B, Durga Prasad B
DOI : 10.18231/j.achr.2020.014
Volume : 5
Issue : 1
Year : 2020
Page No : 70-74
Introduction: Diseases affecting lymph nodes form a wide range of spectrum, from simple infection to
malignant pathology. A panel of IHC markers is decided based on morphologic differential diagnosis.
Aims and Objectives: To study the incidence of lymph nodal lesions with respect to age and sex and
their different histopathological patterns. To use Immunohistochemistry (IHC) for sub typing of neoplastic
lesions.
Materials and Methods: This study was done for a period of two and a half years in the Department
o f Pathology, from Jan 2017 to June 2019. All the specimens received were fixed in 10% formalin and
routinely processed and stained with Hematoxylin and Eosin (H&E.)
Results: A total of 230 lymph node biopsies were studied. Age distribution varied from 3 to 83 years
with female preponderance. Non – Neoplastic lesions were common comprising of 120 cases (52%)
while neoplastic lesions were 110 (48%). Among non neoplastic lesions reactive lymphadenitis (23%) was
common followed by tuberculous lymphadenitis (21%). In neoplastic lesions, metastatic diseases (20%)
predominated. IHC was done wherever necessary for subtyping of lymphomas and also to differentiate
lymphoma from carcinoma.
Conclusion: Lymph node biopsy with IHC plays an important role in establishing the cause for
lymphadenopathy and thus aids in therapy.
Keywords: Lymph node, Immunohistochemistry, Non-neoplastic, Neoplastic.