Authors : Priyadharsini R, Priyadharsini R, Kaviarasan PK, Kaviarasan PK, Abhirami C, Abhirami C, Suba Dharshini B, Suba Dharshini B, Kannambal K, Kannambal K
DOI : 10.18231/j.ijirm.2020.028
Volume : 1
Issue : 3
Year : 2020
Page No : 54-57
Pemphigoid gestationis (PG), also known as herpes gestationis, is a rare autoimmune blistering disease that presents in the second or third trimesters and during the immediate postpartum period. PG is presumably caused by circulating autoantibodies against bullous pemphigoid antigen 180 (BP180) within the basement membrane zone (BMZ). Clinical diagnosis is confirmed with a biopsy and positive direct immunofluorescence. PG tends to recur in subsequent pregnancies with an earlier and more severe presentation. Mild forms can be treated with topical antihistamines and corticosteroids and successful remission occurs with oral corticosteroids. Patients with PG are at greater risk of miscarriages, preterm delivery, still birth, small for gestational age (SGA), transient erythema and blistering. We report a rare case of early onset PG.
Keywords: Pemphigoid gestationis, Autoimmune, Sub epidermal blister, BP180.