Variant hook effect: A cause of false negative result in point of care testing

Authors : Monu Singh, B Preethi, Achla Batra, Pallavi

DOI : 10.18231/j.ijogr.2020.056

Volume : 7

Issue : 2

Year : 2020

Page No : 263-266

Beta Human Chorionic Gonadotrophin (b hCG) assays are sandwich chromatographic immunoassays
which give a false negative results at high hCG concentrations and also in the presence of variants of
hCG like hyperglycosylated hCG and hCG core fragments. This is imperative in everyday clinical scenario
as it delays the diagnosis of pregnancy and its related complications. We have discussed two such cases
where in the first case the diagnosis of hydatidiform mole was delayed due hook effect whereas in the
second case the diagnosis of GTD was missed because of variant hook effect.

Keywords: Hcg – human chorionicganadotropin.

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