Cellular lactate and pyruvate are key intermediates for intra-cellular energy metabolism regulated by Lactate dehydrogenase (LDH) in age-related phenomenon

Authors : Mamata Mishra, Mamata Mishra, Prasanna Kumar Dixit, Prasanna Kumar Dixit

DOI : 10.18231/j.ijcbr.2020.062

Volume : 7

Issue : 2

Year : 2020

Page No : 285-290

Ageing in animals is accompanied by changes in cellular function. Although the cause of aging appears
to be multifactorial, the alterations in cellular functions are the consequence of changes in biochemical
composition of cells since a number of enzymes and metabolites regulate the overall activities of the
cell. There is a great deal to be known about the interrelationship between growth, sexual maturity and
aging in animals. The poikilothermic vertebrates would serve as suitable animal models in which these
parameters could be easily manipulated through variation. In the present study we have used the nonmammalian
vertebrate common Indian toad to find the glycolytic enzyme activity (Lactate dehydrogenase-
LDH) during ageing. We have investigated the LDH activity, pyruvate and lactate content in liver and
muscle and compared if there is any biochemical distinctiveness in the ageing pattern.

Keywords: Aging, Lactate dehydrogenase, Pyruvate, Lactate.

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