Authors : Saquib Alam, Saquib Alam, Kafil Akhtar, Kafil Akhtar, Syed A Abbas, Syed A Abbas, Sheelu S Siddiqui, Sheelu S Siddiqui, Shagufta Moin, Shagufta Moin
DOI : 10.18231/j.ijn.2020.020
Volume : 6
Issue : 2
Year : 2020
Page No : 96-100
Introduction: Although vitamin D insufficiency is very prevalent in Type-2 diabetes mellitus, there are no studies to prove its role or association in diabetic peripheral neuropathy.
Aims and Objectives: We intend to highlight the relationship of Serum Vitamin D levels with Nerve Conduction Velocity in patients of Diabetic Peripheral Neuropathy.
Material and Methods: 52 patients of diabetic neuropathy were assessed for sensory and motor nerve conduction velocity along with serum Vitamin D levels estimation and the results were statistically
analyzed.
Results: Tingling was the most common symptom, seen in 31.1% cases. The numbers of nerve involvement increased with the duration of diabetes mellitus. Majority of the patients showed decrease in SNCV and MNCV in more than three nerves,17(32.69%) and 15(28.84%) cases. 14(87.5%) vitamin D deficient patients had HbA1c levels >11.5. Vitamin D deficiency was more pronounced than insufficiency as the HbA1c levels got increased. The vitamin D deficiency increased in proportion to the duration of disease, with maximum number of vitamin D deficient patients in the disease duration of 11-15 years followed by vitamin D deficient patients with duration of disease>15 years. 36(69.2%) of the diabetic patients were deficient in vitamin D, followed by vitamin D insufficiency in 14(26.9%) (p value<0 value=0.314). >
Conclusions: Nerve conduction velocities and vitamin D deficiency might be independently associated with diabetic peripheral neuropathy, so these investigative parameters could be used as an independent marker to assess the severity of the neuropathy.
Keywords: Diabetes, Peripheral Neuropathy, Nerve Conduction Velocity, Vitamin D.