Authors : Prema Adhikari, Suryakant Nagtilak, Pawan Parashar
DOI : 10.18231/j.ijcbr.2020.074
Volume : 7
Issue : 3
Year : 2020
Page No : 343-348
Background: The risk factors of Metabolic syndrome (Mets), primarily favors the development of
cardiometabolic alteration, type 2 diabetes, hypertension, and dyslipidemia leading to increase in morbidity.
Life style and eating habits often increases the levels of Uric acid (UA) in circulation. Elevated UA &
stress, exacerbates the pain and inflammation. The inflammatory response includes systemic increase in
circulating inflammatory cytokines and acute phase protein, high sensitive C-reactive protein (hs-CRP).
Adiponectin (ADI) a cytokines primarily secreted by adipocytes exerts antidiabetic, anti-inflammatory &
cardioprotective effects. Thus the purpose of the study is to establish a link between Adiponectin, Uric acid
and hs-CRP which may further be used in diagnosis and thus can positively reverse many of the adverse
effects of MetS.
Material and Methods: Present study, an observational case-control study conducted on referred MetS
patients attending OPD at Chhatrapati Shivaji Subharti Hospital, Meerut. Data collected on previously
validated questionnaire from 235 subjects (156 with MetS and 79 non-MetS) assessed for anthropometric
measurements, diabetic profile, ADI, UA & hs-CRP were evaluated by standard established techniques.
Results: The results obtained from Mets patients were compared with non-MetS subjects, where ADI was
significantly lower (P<0>
In Spearman’s rank correlation coefficient for the relationship between ADI and metabolic variables -
ADI was positively correlated with age, diastolic blood pressure, total cholesterol, HDL-C& LDL-C
while negatively correlated with BMI, systolic blood pressure, fasting glucose, Triglyceride& VLDL-C.
Serum hs-CRP levels were elevated with the increasing number of MetS components, being higher among
those with > 2 components of MetS while adiponectin decreasing with the number of MetS components.
Decreased levels were reported for ADI, whereas hs-CRP & UA levels were escalating.
Conclusion: Higher levels of hs-CRP & Uric Acid with lower level of ADI associated with significantly
higher risk of MetS.
Keywords: Obesity, Adiponectin, Uric acid, hs-CRP, Metabolic syndrome.