Authors : Megha Rani N, Prathima K Shetty, S N Rao, Roopa P Nayak
DOI : 10.18231/j.ijpp.2020.028
Volume : 7
Issue : 3
Year : 2020
Page No : 164-167
Context: We have abundant plant resources with many health benefits. Use of plant material for health
benefits will help in reduce the cost of drugs and also provide a substitute drug that is less expensive.
Coleus amboinicus is plant largely distributed in Dakshina kannada and is used for its medicinal properties
as household cure.
Aim: We planned to find out the anti-inflammatory and peripheral analgesic activity of Aqueous Extract of
leaves of Coleus amboinicus.
Settings and Design: Wistar albino rats were randomly selected and tests were performed by dividing the
animals into three groups- control, standard, test.
Materials and Methods: Aqueous extract of leaves of Coleus amboinicus was prepared using soxhlet
apparatus. The dose of leaf extract used was 500mg/kg.
Statistical Analysis: Data was analysed by applying one way ANOVA followed by Dunnets multiple
comparison test using Graphpad Instat.
Results: The results obtained were statistically significant. In Carragenan induced inflammation model
significant inhibition of inflammation was shown by the test drug at the end of 3 hrs and in Acetic acid
induced writing test significant inhibition of occurrence of writhes was noted by the test drug.
Conclusion: This study validates the folkloric use of aqueous extract of leaves of Coleus amboinicus
(AECA) at the dose of 500mg/kg for its anti-inflammatory and peripheral analgesic activity.
Keywords: Coleus amboinicus, Aqueous extract, Antiinflammatory, Carragenan induced writhing test, Acetic acid induced writhing test.