Authors : Manasa R, Manasa R, Prakruthi M, Prakruthi M, Shekhara Naik R, Shekhara Naik R, Mahesh Shivananjappa, Mahesh Shivananjappa
DOI : 10.18231/j.ijnmhs.2020.015
Volume : 3
Issue : 3
Year : 2020
Page No : 73-77
Neurological outcomes like learning, memory and cognition are influenced by the gut microbiota
(GM). These commensal GM modulates behavior and brain development and has implications in
many neurological disorders like Alzheimer’s disease, Parkinson’s disease (PD), anxiety, stress, multiple
sclerosis, etc. PD is a neurodegenerative disease which causes dysbiosis, a-synucleinopathy and affects the
gut-brain axis which includes CNS (Central nervous system), ANS (Autonomic nervous system) and ENS
(Enteric nervous system). There is a bidirectional communication between the brain and the gut called “gut
microbiota-brain axis (GMBA)” and its dysfunction causes numerous diseases. This review focuses on the
inter-relationship between the gut microbiome and the Parkinson’s disease.
Keywords: Parkinson’s disease (PD) gut microbiota (GM) gut microbiota-brain axis (GMBA) cytokine response toll-like receptors.