Authors : Poonam Arora, Manisha Jain, M L Gupta
DOI : 10.18231/j.ijpo.2020.129
Volume : 7
Issue : 4
Year : 2020
Page No : 657-660
Juvenile Myelomonocytic Leukemia (JMML) is an infrequent pediatric myelodysplastic – myeloproliferative neoplasm characterized by the proliferation of myelomonocytic cells. The incidence of JMML is estimated to be 0.13 cases annually per 100000 children aged from 0-14 years. JMML is difficult to diagnose due to its similar clinical and bone marrow findings with that of other myeloproliferative neoplasms such as Chronic Myeloid Leukemia. Some characteristic features that establish the diagnosis of JMML are the presence of monocytosis (>/=1x 109/L), blast percentage in blood and bone marrow of <20>.
Keywords: Juvenile myelomonocytic leukemia (JMML), Myelodysplastic-myeloproliferative neoplasm, Monocytosis, Periorbital swelling.