Authors : Rajat Shukla, A K Singh, Sumeet Arora, A R Rajan, Ajai Kumar Tentu
DOI : 10.18231/j.pjms.2020.052
Volume : 10
Issue : 3
Year : 2020
Page No : 250-257
Background: Loculated pleural effusion is one of the most common clinical entities which are usually caused by empyema, tubercular pleural effusion, malignancy, and hemothorax. The role of Intra-pleural Fibrinolytic Therapy (IPFT) with various fibrinolytics has been studied, however its clinical, radiological and functional outcomes are not assessed completely.
Objective: This is a pre and post intervention study conducted at tertiary care hospital to assess the role of IPFT with streptokinase in patients with loculated pleural effusion.
Results: 102 patients underwent IPFT with streptokinase. Out of 102 patients, 84 patient were male and 18 were females. Main preprocedure diagnosis were tuberculosis (n=70), pneumonia (n=21) and malignancy (n=11). The patients were subdivided into three groups based on sonologically assessed amount of intrapleural fluid - Group 1 (<100ml>200ml). During pre and post IPFT procedure the number of patients identified in group 1 were 30 and 80, group 2 were 40 and 22, group 3 were 32 and none respectively. The mean residual pleural fluid drained before and after IPFT were 190.80ml and 57.84ml (p value<0>
Conclusion: IPFT with streptokinase is a safe option in loculated pleural effusion with no major adverse effects.
Keywords: Intrapleural Fibrinolytic Therapy, Loculated pleural effusion, Fibrinolytics.