Authors : Gittwa Vatsaraj Kottangal, Gittwa Vatsaraj Kottangal, Geeta Vidyadharan, Geeta Vidyadharan
DOI : 10.18231/j.achr.2021.029
Volume : 6
Issue : 2
Year : 2021
Page No : 120-124
Hairy cell leukemia (HCL), a rare, chronic B-cell leukemia, first described as a distinct entity in 1958, was recognized as an entity by the World Health Organization in 2008. The disease accounts for 2% of all leukemias and is more frequent in middle-aged to older men. The diagnosis is based on the hairy lymphoid cells in the peripheral smear and the bone marrow aspiration cytology and the bone marrow biopsy showing a monotonous interstitial infiltrate with a fried egg appearance. The classic immunophenotypic profile in the flow cytometry and the BRAF V600E mutation confirm the diagnosis. Herein we report a 52-
year-old male patient presented with pancytopenia, high-grade fever, and weight loss. The characteristic histomorphological and the flow cytometry features of this leukemia will be used to discuss further the recent updates on the distinct clinicopathologic features, differential diagnosis, treatment, and prognosis of the entity.
Keywords: Hairy cell leukemia, Monotonous, Fried egg, Flow cytometry, Pancytopenia.