Authors : IP Ezeugwunne, IP Ezeugwunne, N Mbachu, N Mbachu, PC Arinzechi, PC Arinzechi, EC Ogbodo, EC Ogbodo, RA Analike, RA Analike, IO Uduchi, IO Uduchi, ECO Izuchukwu, ECO Izuchukwu, NS Nduka, NS Nduka
DOI : 10.18231/j.ijnmhs.2021.032
Volume : 4
Issue : 4
Year : 2021
Page No : 182-189
This study evaluated the serum concentrations of Immunoglobulin M and Immunoglobulin A in individuals with TB, HIV and HIV-TB co-infection in Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi South East, Nigeria. A total of 80 participants (males=44; females=36), with a mean age of 35.83±7.3 were randomly recruited by convenient sampling technique from patients attending TB-DOTS and HIV Clinics in NAUTH and grouped as: TB positive individuals (Group I), HIV-TB co-infection (Group II), HIV positives (Group III), and control (Group IV). 5mls of venous blood samples were collected from each participants using plain containers for estimation of immunoglobulin A and M classes by Immuno-turbidimetric Method. The results obtained showed that mean serum levels of IgM (78.14±42.41 and IgA (374.45±15.69) were significantly increased in participants with HIV-TB co-infection when compared with TB (49.21±3.67) and (315.41±52.79), HIV (41.91±25.97) and (342.23±92.67 and control groups (55.82±35.36) and (322.66±71.34) at p<0 p=0.048), p=0.000) p=0.001) p=0.013) p=0.005),>
Keywords: HIV, TB, HIV-TB co-infection, Immunoglobulins, NAUTH.