Authors : Mukesh Maity, Krishna Chandra Maity, Saikat Hazra, Arnab Kheto, Samik Banerjee, Sinchan Das
DOI : 10.5530/fra.20260001
Volume : 16
Issue : 1
Year : 2026
Page No : 1-11
It is becoming more well recognized that Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a self-sustaining mucosal ecosystem in which oxidant-antioxidant imbalance, microbial dysbiosis, stromal remodeling, type 2 immunological polarization, and epithelial damage support each other. This paper critically summarizes redox dysregulation in CRSwNP and assesses whether Teucrium marum Varum (TMV), a Mediterranean Lamiaceae taxon rich in terpenoids, provides a physiologically feasible pathway to modifying this axis based on mechanistic considerations. Using a Boolean concept-block method and PRISMA-informed search and reporting framework reporting standards, an organized narrative search of PubMed, Scopus, Web of Science, and Google Scholar (2015-2026) reduced 487 de-duplicated data to 47 included sources. Quantitative analysis of tissue-biomarker and radical-scavenging data reveals quantifiable KEAP1-NRF2-HO-1 activation in CRSwNP tissue, which is still outpaced by oxidant accumulation. It also identifies TMV chemotypes enriched in (E)-β-caryophyllene and dolichodial as mechanistically, but not directly, convergent on this deficit. There are no CRSwNP-specific data available for T. marum varum. The next phase is not empirical application, but rather chemotype-standardized, biomarker-anchored preclinical testing. Keywords: Chronic Rhinosinusitis with Nasal Polyps, Nrf2-Keap1 signalling, Oxidative Stress, Phytochemical antioxidants, Teucrium marum, β-caryophyllene.