Authors : P. R. Logesh Kumar and Dr. Girendra Gautam
DOI : 10.20959/wjpps201811-12659
Volume : 7
Issue : 11
Year : 2018
Page No : 1410-1417
The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides, thiamine (vitaminB1) and alloxan. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Although pyrimidine derivatives such as uric acid and alloxan were known in the early 19th century, a laboratory synthesis of a pyrimidine was not carried out until 1879, when Grimaux reported the preparation of barbituric acid from urea and malonic acid in the presence of phosphorus oxychloride.