SYNTHESIS OF A SERIES OF THIAZOLIDINONE DERIVATIVES AND EVALUATION OF THEIR ANTIMICROBIAL PROPERTIES

Authors : Pankaj Baboo, Girendra Gautam, S K Gupta

DOI : 10.7897/2230-8407.080461

Volume : 61

Issue : 4

Year : 2017

Page No : 121-125

A series of thiazolidinone derivatives with various aromatic aldehyde substitution were synthesized and characterized by physical (TLC and M.P.) and spectral data (IR, NMR and MASS). They were evaluated for antimicrobial potential against Gram positive Staphylococcus aureus, Bacillus subtilis, gram-negative Escherichia coli, Pseudomonas aeuroginosa, Shigella and fungi Candida albicans and Aspergillus niger. The initial screening using zones of inhibition at 50 μl concentration revealed that they are moderately active against the tested strains.


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