Authors : Kaliyan Barathikannan, Ramachandran Chelliah, Host Antony David, Edvina Princy Kulandairaj, Selvakumar Vijayalakshmi, Momna Rubab, Deog-Hwan Oh
DOI : 10.1016/b978-0-443-22188-0.00021-8
Volume : 1
Issue : 2
Year : 2025
Page No : 397-415
Postbiotics, a microbiome innovation, refers to nonviable microbial cells, metabolic byproducts, and their microbial components released after lysis. Modulating the immune response and gene expression, blocking pathogen binding, preserving intestinal barriers, and preventing carcinogenesis and pathogen infections are all benefits of postbiotics. Postbiotics possess antibacterial, antioxidant, and immunomodulatory activities that promote positive physiological, immunological, neurohormonal, regulatory, and metabolic responses. Postbiotics alleviate SARS-CoV-2 and other symptoms. Postbiotics can replace preprobiotics in immunosuppressed patients, children, and preterm neonates. Postbiotics are utilized in cosmetics, food preservation, and biofilm removal. Postbiotics have many advantages over live bacteria, including no risk of gut-to-blood bacterial translocation or antibiotic-resistance gene acquisition. Postbiotic extraction, standardization, transport, and storage are more natural. Fermentation, high pressure, and other bioengineering methods can synthesize different postbiotics. Postbiotics can cause stomach pain, sepsis, and toxic shock, thus safety and quality are crucial. Postbiotic studies may increase host health and physiological processes. This chapter covers postbiotic research's latest developments.