Authors : Almoe iz Y. Hammad, Maha E. Osman and Warda S. Abde lgadir
Volume : 7
Issue : 1
Year : 2013
Page No : 21 -25
Acrylamide is a toxic, cancer -causing, industr ial chemical used pr imar ily in the preparation of polyacrylamide, which is used pr incipally in water and wastewater treatment and in pulp and paper processing. A significant source of dietary acrylamide is foods cooked at high temperature. Till recently, only known human health effect is neurotoxicity at relatively high doses occur r ing through occupational exposures. Numerous gaps in knowledge concerning the formation, dietary exposure, and potential for adverse health r isks of acrylamide were identified, and the resulting recommendations called for additional research on these topics. Hence the objective of this study was to assess the effects of dietary acrylamide at different doses on tissues and blood of Wistar rats. The results showed no evidence of carcinogenic effect of acrylamide on any of the vital organs, but the main features were growth depression and pathological changes on the liver, kidneys and intestines sufficient to impose significant haematological changes.