Authors : Alireza Pourrahim, Maryam Kheiry
Volume : 13
Issue : 3
Year : 2026
Page No : 10-18
Introduction: Myocardial infarction induces IRI, leading to cardiomyocyte necrosis, neutrophil-driven inflammation, and fibroblast-mediated fibrosis, culminating in ventricular dysfunction. Stem Cell such as MSCs promote angiogenesis via VEGF/HGF paracrine secretion; CPCs differentiate through Notch/Wnt for tissue replacement; iPSCs enable patient-specific remuscularization with Cx43 integration. Aim: The purpose of this study is to investigate the role of stem cells in cardiac tissue repair after myocardial infarction via physiological mechanisms. Discussion: Stem cell–based therapies represent a promising yet evolving approach for cardiac repair following myocardial infarction. Preclinical models consistently demonstrate improvements in angiogenesis, attenuation of fibrosis, and partial restoration of ventricular function; however, these outcomes have not been fully replicated in clinical trials. Conclusion: This review synthesizes mechanisms for advancing clinical translation. the future of cardiac regenerative medicine lies in the integration of mechanistic insights with bioengineering and molecular innovation.