Authors : Venkatesan Natarajan, Arman Dalal, Radhika Tippani, Abdul Ajeed Mohathasim Billah, Shoheb Shakil Shaikh, Suresh V. Chinni, Kiruba Mohandoss
DOI : 10.1016/b978-0-443-41561-6.00002-9
Volume : 1
Issue : 2147483647
Year : 2026
Page No : 203-223
This chapter overviews the new science of artificial gametes, ready to transform reproductive biology and biotechnology. Leveraging developments in nanotechnology, stem cell science, and genetic engineering, artificial gametes open up untold promise in the reversal of fertility, prenatal disease prevention, and reproductive inclusivity across a variety of population categories, including lesbian, gay, bisexual, transgender, and queer individuals and the infertile people. The chapter examines the molecular basis of gametogenesis, the integration of synthetic gametes into artificial wombs, and the future of xenogametes and post-species reproductive engineering. It also explores bioethical and legal concerns of synthetic gametes, including genetic manipulation, germline editing, and regulation of these technologies. The discussion also encompasses the potential impact of predictive models and digital twins on reproductive planning and how the creation of synthetic life beyond conventional biological standards has promised and presented challenges.