Authors : Shipra Shrivatsava
DOI : 10.18231/j.ijcbr.2022.029
Volume : 9
Issue : 2
Year : 2022
Page No : 148-153
Background: This study was undertaken to estimate the serum creatinine and uric acid levels in subclinical, overt hypothyroid cases and healthy controls and correlate these parameters with TSH in hypothyroid cases.
Materials and Methods: Study included 60 patients of newly diagnosed hypothyroidism, of which 30 were subclinical and 30 were overt cases. 80 age sex matched healthy controls were taken. Venous blood was used for estimation of serum fT3, fT4, TSH, uric acid and creatinine levels. Statistical analysis was done using unpaired t' test. Correlation between creatinine, thyroid parameters and uric acid was done.
Results: There was significant elevation in serum levels of creatinine and uric acid in subclinical and overt hypothyroidism cases when compared to controls. Overt cases had significantly higher creatinine and uric acid levels in comparison to subclinical hypothyroid cases. Significant positive correlation with TSH was shown by both creatinine and uric acid.
Conclusions: Both subclinical and overt hypothyroidism cases are associated with elevated serum creatinine and uric acid levels.
Keywords: Hypothyroidism, Creatinine, Uric acid, Gout.