Authors : Cristian C. Gavăt*, Constantin V. Uglea and Costinela Valerica Georgescu
Volume : 58
Issue : 6
Year : 2013
Page No : 479-489
Bioreactive polysaccharides have been most commonly used as drugs or drug delivery systems. The present paper describes the biological activity of some artificial and natural polyanionic polysaccharides. Results regarding oxidized cellulose and carboxymethylcellulose modified with benzocaine or N hydroxy 3,4 dihydroxy benzamide (Didox) complete the picture of antiviral and antitumoral effects of polysaccharides. The biological tests regarding antiviral and antitumor activity showed that the introduction of benzocaine as a spacer unit between the main chain and a CMC carboxylic group enhances the antiviral and antitumor activity of carboxymethylcellulose. Author Keywords: natural polysaccharides, benzocaine, Didox, antiviral activity, antitumor activity, LENTINUS-EDODES.