Authors : Payal P. Gaikwad 1 , Pooja P. Gaikwad 2* , Rahul N. Patil 3* , Shweta H. Zalte 4 , Nilam S. Sanas 5 , Jyoti E. Sonawane 6 , Priti A. Kothawade 7
Volume : 35
Issue : 2
Year : 2025
Page No : 163-170
Background: Considering the prevalence of epilepsy and the problems Salvia officinalis Linn., associated with currently available anti-epileptic drugs like side effects, resistance, safety issues and high cost, herbal medicines with fewer complications could be very appropriate alternative. Therefore, the present study was examined for the anti-epileptic activity of ethanolic extract of Salvia officinalis Linn. stem. Material and Methods: Earlier studies suggested that Phyto-constituents like flavonoid, alkaloid and tannins shows anti-epileptic activity and comprehensive literature revealed that Salvia officinalis is rich in flavonoids like chlorogenic acid, ellagic acid, quercetin, rosmarinic acid, as well as the several volatile components such as borneol, cineole, camphor, and thujone, alkaloids, tannins, polyphenol, saponins etc. Anti-epileptic activity of Salvia officinialis. Linn stem in mice was evaluated using Pentylenetetrazole (PTZ) induced seizures, Strychnine induced convulsion and Picrotoxin induced convulsion GABA estimation method. Result: The ethanolic extract at 100 mg/kg, 200 mg/kg and 400 mg/kg possess dose dependent anticonvulsant activity as it reduced the duration of seizures produced by and latency of seizures produced by PTZ, Strychnine, and Picrotoxin. The amount of GABA estimation which is most likely to be involved in seizure activity was increased in mice brain and the anti-epileptic activity of ethanolic extract of Salvia officinalis Linn. stem is justified.