Authors : Usha Kiran P., Sandeesha V., Lakshmana Kumar N.
DOI : 10.14260/jemds/2019/543
Volume : 8
Issue : 31
Year : 2019
Page No : 2495-2499
BACKGROUND Hypothyroidism is associated with insulin resistance and hyperlipidaemia. Insulin resistance is the reason behind type 2 diabetes mellitus and is found in mild thyroid dysfunction with increased risk of dyslipidaemia. Prevalence of type 2 diabetes mellitus and cardiovascular risk is more common in hypothyroidism. Hence regular screening of blood glucose and lipid profile in hypothyroidism individuals may prevent dreaded complications. The aim of this study to evaluate the role of thyroid dysfunction on alteration of glucose and lipid metabolism leading to insulin resistance, an important risk factor for cardio vascular diseases. METHODS In this study, we included 50 subjects, aged 25 to 35 years. This is a case control study conducted in the department of Biochemistry. Investigations like fasting and post prandial blood sugar, HbA1c and lipid profile (Cholesterol, Triglycerides, HDL, LDL & VLDL) were done. Blood pressure was measured. Body weight and height were measured, and BMI was calculated. All the parameters were analysed using XL 640 fully automated random-access analyser. Data was analysed using GraphPad QuickCalcs software. RESULTS The cases were selected based on T4 and TSH concentrations whose values were significantly decreased and elevated respectively. The patients with hypothyroidism exhibited significant increase in concentration of total cholesterol, LDL, fasting blood glucose and HbA1c while HDL (p<0.05) showed a decrease in its concentration in comparison to controls. BMI and diastolic blood pressure showed significant elevation in hypothyroid individuals when compared to controls. CONCLUSIONS It is evident from this study that insulin resistance may lead to T2DM in individuals with thyroid dysfunction. Disturbed lipid metabolism may eve