Authors : *Syed Saif Imam, Ravi Sharma
DOI : 10.35629/7781-0802552558
Volume : 8
Issue : 2
Year : 2023
Page No : 552-558
he most deadly sort of cancer of all is lung cancer, which is quite serious. Natural substances including Formononetin, Matrine, Kaempferol, TransResveratrol, and Apigenin are extremely effective anti-inflammatory and anti-cancerous compounds that can inhibit the signal transduction pathways for ERK-MAPK, JAK-STAT, p38, AMPK, PI3K/Akt, mTOR, STAT3, and wnt/-catenin. Inflammatory and proliferator enzymes such COX-2, caspase-3, MMP-9, MMP-2, NF-B, p53, Bcl-xL, Bcl-2, Mcl1, miR-210, cyclin D1, iNOS, IL-1, TNF-, IFN-, IL-6, and IL-1 are inhibited by these APIs. The issues are caused by the aforesaid qualities' instability at the pH of the gastrointestinal system, which clearly demonstrates their anti-cancerous potential.At stomach pH, all substances either decay or lose their ability to cause cancer. Transferosomes are a type of new generation nanoparticle that is highly stable at 7.4 pH and has superior effectiveness and drug trapping potential than other types of traditional nanoparticle systems. If these APIs are included inside the transferosome's nano-vesicular structure, loaded in pMDI canisters like fluorocarbon polymerization (FCP) plasma coated canisters with a better propellant like HFA-134a, and delivered with the aid of spacers, it is possible to treat lung cancer affordably, effectively, with few side effects, and it also ensures that the cancer won't return