Hypoglycemic and Antioxidant Effect of Anthocleista Grandiflora Hydro-Ethanol Extract in Alloxan Induced Diabetic Rats
Background
Diabetes is characterized by insulin deficiency or cell resistance to insulin leading to hyperglycemia accompanied by impaired antioxidant
defense mechanisms. The aim of the study was to evaluate the hypoglycemic and antioxidant effect of Anthocleista grandiflora wood bark hydroethanol extract in albino rats.
Materials/Methods
The wood bark was extracted with 30:70 percent hydro-ethanol using soxhlet extraction method. 150mg/kg of alloxan was used to induce
diabetes in the rats. Thirty (30) male albino rats were randomized into six (6) groups of five (5) rats each. Group 1 served as a negative control.
Group 2 served as diabetic control (induced untreated). While, groups 3, 4, 5, and 6 were induced and treated with 22.5 mg/kg of metformin, and
100, 200, and 300 mg/kg of Anthocleista grandiflora extract for 21 days.
Results
The results showed a significant (p
Diabetes is characterized by insulin deficiency or cell resistance to insulin leading to hyperglycemia accompanied by impaired antioxidant
defense mechanisms. The aim of the study was to evaluate the hypoglycemic and antioxidant effect of Anthocleista grandiflora wood bark hydroethanol extract in albino rats.
Materials/Methods
The wood bark was extracted with 30:70 percent hydro-ethanol using soxhlet extraction method. 150mg/kg of alloxan was used to induce
diabetes in the rats. Thirty (30) male albino rats were randomized into six (6) groups of five (5) rats each. Group 1 served as a negative control.
Group 2 served as diabetic control (induced untreated). While, groups 3, 4, 5, and 6 were induced and treated with 22.5 mg/kg of metformin, and
100, 200, and 300 mg/kg of Anthocleista grandiflora extract for 21 days.
Results
The results showed a significant (p