Authors : Abdullahi MH, Ashikaa BA, Abdullahi HS, Akyengo O and Abdullahi AB
DOI : 10.19080/JCMAH.2023.12.555838
Volume : 12
Issue : 3
Year : 2023
Page No : 1-6
Background Diabetes is characterized by insulin deficiency or cell resistance to insulin leading to hyperglycemia accompanied by impaired antioxidant defense mechanisms. The aim of the study was to evaluate the hypoglycemic and antioxidant effect of Anthocleista grandiflora wood bark hydroethanol extract in albino rats. Materials/Methods The wood bark was extracted with 30:70 percent hydro-ethanol using soxhlet extraction method. 150mg/kg of alloxan was used to induce diabetes in the rats. Thirty (30) male albino rats were randomized into six (6) groups of five (5) rats each. Group 1 served as a negative control. Group 2 served as diabetic control (induced untreated). While, groups 3, 4, 5, and 6 were induced and treated with 22.5 mg/kg of metformin, and 100, 200, and 300 mg/kg of Anthocleista grandiflora extract for 21 days. Results The results showed a significant (p<0.001) increase in glucose levels in the diabetic control compared to the negative control. Treatment with the plant extract showed a significant (p<0.001) dose-independent decrease in glucose level compared to the diabetic control group, and higher than the metformin-treated group. The liver and kidney antioxidants showed a significant (p<0.001) decrease in superoxide dismutase, catalase, glutathione peroxidase, and reduced glutathione, with a significant (p<0.001) increase in malondialdehyde level in diabetic control. Treatment with the extract showed a significant (p<0.001) increase in superoxide dismutase, catalase, and reduced glutathione, with a significant (p<0.001) decrease in malondialdehyde level compared to the diabetic control group, and higher than the metformin-treated group in the liver. Conclusion This study concluded that the hydro-ethanol extract of Anthocleista grandiflora showed potent hypoglycemic and antioxidant properties. Hence, the extract could be used for the treatment and management of diabetic complications.