Authors : Sunita Ghike, Sheela Jain, Bhavna Kumare, Madhur Gupta, Chaitnya Shembekar
Volume : 3
Issue : 2
Year : 2011
Page No : 71-74
Elevated plasma homocysteine level is a risk factor for vascular problems, including atherosclerosis and arterial thrombosis. Hyperhomocysteinemia during pregnancy causes endothelial dysfunction as a result of increased oxidative stress. The ultimate results are vasculopathy and dysfunction. The aim of the study was to find the association of the homocysteine levels in pre-eclampsia and normal pregnancy and to know, if there correlation between serum homocysteine levels and severity of Study design: Prospective case control Study place: Women attending antenatal OPD or admitted in antenatal ward of Department of Obstetrics and Gynecology, Study duration: 1 March 2010 to 1 September 2010 Study population and sample Group 1: 30 pregnant normotensive healthy women, GA 28 to 42 weeks and fulfilling inclusion Group 2: 30 pregnant women, GA 32 to 42 weeks with pre-eclamptic toxemia (mild and severe) and meeting inclusion 30 pre-eclamptic women were matched with 30 normotensive women of same gestational Results: Mean level of homocysteine was significantly raised in pre-eclamptic women than in control The rise in mean serum homocysteine level was more in women with severe PET as compared to those with mild PET, though not statistically significant. The women in pre-eclamptic group having increased homocysteine levels showed increased incidence of IUGR, IUD, still birth and abruptio and increased incidence of cesarean Conclusion: It is concluded from our study that serum homocysteine levels were significantly elevated in women with PET compared with control and strong correlation may exist between serum homocysteine levels and severity of pre-