Levels of Tumor necrosis factor – alpha in pre – eclampsia

Authors : Madhur Gupta, Suresh Chari, Manju Chandankhede, Sunita Ghike

DOI :

Volume : 1

Issue : 2

Year : 2011

Page No : 24-26

Background : Preeclampsia is a severe complication of pregnancy characterized by an excessive maternal systemic inflammatory response with activation of the immune system. Material and Method: 25 of preeclampsia (i.e., high blood pressure [BP] and proteinuria) and 15 of normal pregnancy were enrolled for the study. The blood samples were analysed for tumor necrosis factor-alpha. Result: Significantly increased values of TNF-á were found in preclampsia when compared to normal pregnant females. Discussion : TNF- á, is a potential mediator of endothelial dysfunction, which is a hall mark of the maternal syndrome of preclampsia. Key Words : Pre- eclampsia, TNF-alpha.