Authors : Manju Chandankhede, Madhur Gupta
Volume : 3
Issue : 2
Year : 2014
Page No : 29-33
Cardiovascular disease (CVD) is a major vascular complication in patients with type 2 diabetes and diabetic patients are at increased risk of cardiovascular mortality compared to non diabetic subjects. Abnormally high levels of free radicals and inflammation can lead to damage of cellular organelles, enzymes, increased lipid peroxidation and development of insulin resistance and these consequences can promote the development of complications of diabetes mellitus. We evaluated and correlated the diabetic patients for risk factors for CVD like malondialdehyde, homocysteine, High sensitive C reactive protein (hs-CRP) and lipid profile in 50 patients of Non insulin dependent diabetes mellitus (NIDDM) with disease duration less than 10 years (group II), 50 NIIDM patients with disease duration more than 10 years (group III) and 50 normal healthy controls (group I). There was significant increased levels (p-value) of all the parameters except HDL cholesterol which were decreased in group III when compared with group II and group I but no significant difference observed between parameters in group I & group II. There was positive correlation between hs-CRP to the MDA, serum cholesterol and HbA1c &also between MDA and homocysteine in group III patients. Our findings indicate that both oxidative stress and inflammation form a vicious cycle and are common mediator in the pathogenesis of accelerated atherosclerosis in the diabetic patients.